Death toll: 259,494 smokers (all men)

If you thought ditching a cellphone carrier was tough, try quitting nicotine. Each year, 35 million Americans attempt to stop smoking; only 1 million succeed. The reasons to quit are powerfully persuasive—dramatic reductions in risk of stroke, heart disease and certain cancers register within mere years—but logic is no match for tobacco's seduction. "Relapses are most likely to hit in the late afternoon and evening," says Saul Shiffman, Ph.D., a professor of psychology at the University of Pittsburgh's smoking research group. "The classic situation is where there are other smokers and alcohol."

Survive it: Nicotine cravings are short-lived, usually lasting three to four minutes. If you're at a bar (or a party), get through the moment by chugging a glass of water and striking up a conversation with anyone close by, even a complete stranger. "Cold water kills the urge. Talking distracts and delays, and it encourages deeper breathing, which reduces stress," says Alan Peters, M.T.T.S., lead counselor for QuitNet.com. "Try opening a conversation by saying, 'You know, I quit smoking, and right now I'm thinking of having a cigarette.'" And if the person offers you one? Imagine that you-know-who's skeletal hand is proffering the pack.